Simon, J.M., Paranjape, S., Wolter, J.M., Salazar, G., Zylka, M.J. (2019) High-throughput screening and classification of chemicals and their effects on neuronal gene expression using RASL-seq. Scientific Reports 9, doi:10.1038/s41598-019-39016-5.

Loo, L., Simon, J.M., McCoy, E.S., Niehaus, J.K., Zylka, M.J. (2019) Single-cell transcriptomic analysis of mouse neocortical development. Nature Communications 10, doi:10.1038/s41467-018-08079-9.

Tuttle, A.H., Molinaro, M.J., Jethwa, J.F., Sotocinal, S.G., Prieto, J.C., Styner, M.A., Zylka, M.J. (2018). A deep neural network to access spontaneous pain from mouse facial expressions. Mol. Pain 1744806918763658 , doi: 10.1177/1744806918763658.

McCoy, E.S., Taylor-Blake, B., Aita, M., Simon, J.M., Philpot, B.D., Zylka, M.J. (2017). Enhanced Nociception in Angelman Syndrome Model Mice. J. Neurosci. 42: 10230-10239. doi: 10.1523/JNEUROSCI.1018-17.2017.

Piven, J., Elison, J.T., Zylka, M.J. (2017). Toward a conceptual framework for early brain and behavior development in autism. Mol. Psychiatry 10: 1385-1394, doi: 10.1038/mp.2017.131. Epub 2017 Jul 25.

Yi, J.J., Paranjape, S.R., Walker, M.P., Choudhury, R., Wolter, J.M., Fragola, G., Emanuele, M.J., Major, M.B., Zylka, M.J. (2017). The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome. J. Biol Chem. [ePub ahead of print] doi: 10.1074/jbc.M117.788448

Tuttle, A.H., Bartsch, V.B., Zylka, M.J. (2016) The Troubled Touch of Autism. Cell 166: 273-274, doi: 10.1016/j.cell.2016.06.054.

Mabb, A.M., Simon, J.M., King, I.F., Lee, H.M., An, L.K. Philpot, B.D., Zylka, M.J. (2016) Topoisomerase 1 Regulates Gene Expression in Neurons through Cleavage Complex-Dependent and -Independent Mechanisms. PLoS One 11:e0156439, doi: 10.1371/journal.pone.0156439

Pearson, B.L., Simon, J.M., McCoy, E.S., Salazar, G., Fragola, G., Zylka, M.J. (2016). Identification of chemicals that mimic transcriptional changes associated with autism, brain aging and neurodegeneration. Nature Communications 7, doi:10.1038/ncomms11173.

Ehlen, J., Jones, K., Pinckney, L., Gray, C., Burette, S., Weinberg, R., Evans, J., Brager, A., Zylka, M.J., Paul, K., Philpot, B., DeBruyne, J. (2015). Maternal Ube3a loss disrupts sleep homeostasis but leaves circadian rhythmicity largely intact.  J. Neurosci.  35:13587-13598.

Yi, J.J., Berrios, J., Newbern, J.M., Snider, W.D., Philpot, B.D., Hahn, K.M., Zylka, M.J. (2015).  An autism-linked mutation disables phosphorylation control of UBE3A.  Cell 162:795-807.

Brings, V.E., Zylka, M.J. (2015). Sex, drugs, and pain control. Nat. Neurosci. 18:1059-1060.

Zylka, M.J.#, Simon, J.M., Philpot, B.D. (2015). Gene length matters in neurons.  Neuron 86:353-355.  # = corresponding author.

Loo, L., Wright, B.D., Zylka, M.J. (2015) Lipid kinases as therapeutic targets for chronic pain.  Pain. Apr, 56 Suppl 1:S2-S10.

Wright, B.D., Simpson, C., Stashko, M., Kireev, D., Hull-Ryde, E.A., Zylka, M.J.#, Janzen, W.P.# (2015) Development of a high-throughput screening assay to identify inhibitors of the lipid kinase PIP5K1C.  J. Biomol. Screen 20:655-662.  # = co-senior authors.

McCoy, E., Street, S., Taylor-Blake, B., Yi., J., Edwards, M., Wightman, M., Zylka, M. (2014) Deletion of ENTPD3 does not impair nucleotide hydrolysis in primary somatosensory neurons or spinal cord.  F1000Res.  2014 Jul 21 [revised 2014 Sep 19];3:163. doi: 10.12688/f1000research.4563.2.

McCoy, E.S., Zylka, M.J. (2014) Enhanced behavioral responses to cold stimuli following CGRPα sensory neuron ablation are dependent on TRPM8.  Mol. Pain 10:69.  

Mabb, A.M., Kullmann, P.H., Twomey, M.A., Miriyala, J., Philpot, B.D., Zylka, M.J. (2014) Topoisomerase 1 inhibition reversibly impairs synaptic function.  Proc. Natl. Acad. Sci. USA 111:17290-17295.

Zylka, M.J., Philpot, B.D., King, I.F. (2014) Zylka et al. reply to Bias towards large genes in autism. Nature 512:E2.

Huang, H.S., Yoon, B.J., Brooks, S., Bakal, R., Berrios, J., Larsen, R.S., Wallace, M.L., Han, J.E., Chung, EH., Zylka, M.J., Philpot, B.D. (2014) Snx14 regulates neuronal excitability, promotes synaptic transmission, and is imprinted in the brain of mice.  PLoS One. 9:e98383.

Wright, B.D., Loo, L., Street, S.E., Ma, A., Taylor-Blake, B., Stashko, M.A., Jin, J., Janzen, W.P., Frye, S.V., Zylka, M.J. (2014) The lipid kinase PIP5K1C regulates pain signaling and sensitization.  Neuron 82:836-847.

Rittiner, J.E., Brings, V.E., Zylka, M.J. (2014) Overexpression of diacylglycerol kinase η enhances Gαq-coupled G protein-coupled receptor signaling.  Mol. Pharmacol. 85:800-810.

Coutinho-Budd, J.C., Snider, S.B., Fitzpatrick, B.J., Rittiner, J.E., Zylka, M.J. (2013) Biological constraints limit the use of rapamycin-inducible FKBP12-Inp54p for depleting PIP2 in dorsal root ganglia neurons.  J. Negat. Results Biomed. 12:30.

King, I.F., Yandava, C.N., Mabb, A.M., Hsiao, J.S., Huang, H-S., Pearson, B.L., Calabrese, J.M., Starmer, J., Parker, J.S., Magnuson, T., Chamberlain, S.J., Philpot, B.D., Zylka, M.J. (2013) Topoisomerases facilitate transcription of long genes linked to autism.  Nature 501:58-62.

Street, S.E., Kramer, N.J., Walsh, P.L., Taylor-Blake, B., Yadav, M.C., King, I.F., Vihko, P., Wightman, R.M., Millán, J.L., Zylka, M.J. (2013) Tissue-nonspecific alkaline phosphatase (TNAP) acts redundantly with PAP and NT5E to generate adenosine in the dorsal spinal cord.  J. Neurosci. 33:11314-11322.

McCoy, E.S., Taylor-Blake, B., Street, S.E., Pribisko, A.L., Zheng, J., Zylka, M.J. (2013) Peptidergic CGRPα primary sensory neurons encode heat and itch and tonically suppress sensitivity to cold. Neuron 78:138-151.

Kokel D, Cheung CY, Mills R, Coutinho-Budd J, Huang L, Setola V, Sprague J, Jin S, Jin YN, Huang XP, Bruni G, Woolf CJ, Roth BL, Hamblin MR, Zylka MJ, Milan DJ, Peterson RT. (2013) Photochemical activation of TRPA1 channels in neurons and animals. Nat. Chem. Biol.  9:257-263.

McCoy ES, Lea WA, Mott BT, Maloney DJ, Jadhav A, Simeonov A, Zylka MJ. (2012) High-throughput screen identifies cyclic nucleotide analogs that inhibit prostatic acid phosphatase. J. Biomol Screen. 18:481-489.

Hurt, J.K., Coleman, J.L., Fitzpatrick, B.J., Taylor-Blake, B., Bridges, A.S., Vihko, P., Zylka, M.J. (2012) Prostatic acid phosphatase is required for the antinociceptive effects of thiamine and benfotiamine.  PLoS One 7(10):e48562.

Korboukh, I., Hull-Ryde, E.A., Rittiner, J.E., Randhawa, A.S., Coleman, J., Fitzpatrick, B.J., Setola, V., Janzen, W.P., Frye, S.V., Zylka, M.J., Jin, J. (2012). Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice. J. Med. Chem. 55:6467-6477.

McCoy, E.S., Taylor-Blake, B.T., Zylka, M.J. (2012). CGRPα-expressing sensory neurons respond to stimuli that evoke sensations of pain and itch. PLoS One 7:e36355.

Hurt, J.K., Zylka, M.J. (2012). PAPupuncture has localized and long-lasting antinociceptive effects in mouse models of acute and chronic pain. Mol. Pain 8:28.
Coutinho-Budd, J., Ghukasyan, V., Zylka, M.J., Polleux, F. (2012). The F-BAR domains from srGAP1, srGAP2, and srGAP3 differentially regulate membrane deformation. J. Cell Sci.125:3390-3401.

Hurt, J.K., Fitzpatrick, B.J., Norris-Drouin, J., Zylka, M.J. (2012). Secretion and N-linked glycosylation are required for prostatic acid phosphatase catalytic and antinociceptive activity. PLoS One 7:e32741.
Rittiner, J.E., Korboukh, I., Hull-Ryde, E.A., Jin, J., Janzen, W.P., Frye, S.V., Zylka, M.J. (2012). AMP is an adenosine A1 receptor agonist.  J. Biol. Chem. 287:5301-5309.

Huang, H.S., Allen, J.A., Mabb, A.M., King, I.F., Miriyala, J., Taylor-Blake, B., Sciaky, N., Dutton, J.W. Jr., Lee, H.M., Chen, X., Jin, J., Bridges, A.S., Zylka, M.J.#, Roth, B.L.#, Philpot, B.D.#  (2011). Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons.  Nature 481:185-189. # = co-senior authors

Zylka, M.J., Sowa, N.A. (2011). NT5E mutations and arterial calcifications. N. Engl J. Med. 364:1579.

Street, S.E., Walsh, P.L., Sowa, N.A., Taylor-Blake, B., Guillot, T.S., Vihko, P., Wightman, R.M., Zylka, M.J.  (2011). PAP and NT5E inhibit nociceptive neurotransmission by rapidly hydrolyzing nucleotides to adenosine.  Mol. Pain. 7:80.

Mabb, A.M., Judson, M.C., Zylka, M.J.#, Philpot, B.D.# (2011). Angelman Syndrome: Insights into genomic imprinting and neurodevelopmental phenotypes.  Trends in Neuroscience (Cell Press) 34:293-303.  # = co-senior authors.

Gray, S.J., Foti, S.B., Schwartz, J.W., Bachaboina, L., Taylor-Blake, B., Sun, H., Coleman, J., Ehlers, M., Zylka, M.J., McCown, T.J., Samulski, R.J.  (2011). Optimizing promoters for rAAV-mediated gene expression in the peripheral and central nervous system using self-complementary vectors.  Human Gene Therapy 22:1143-1153.

Zylka, M.J. (2011). Pain-relieving prospects for adenosine receptors and ectonucleotidases.  Trends in Molecular Medicine (Cell Press), 17:188-196.

Street, S.E., Zylka, M.J. (2011). Emerging roles for ectonucleotidases in pain-sensing neurons.  Neuropsychoparmacology 36: 358.

Zylka, M.J. (2010). Needling adenosine receptors for pain relief.  Nat. Neurosci. 13:783-784.

Sowa, N.A., Street, S.E., Vihko, P., Zylka, M.J. (2010). Prostatic acid phosphatase reduces thermal sensitivity and chronic pain sensitization by depleting phosphatidylinositol 4,5-bisphosphate.  J. Neurosci. 30:10282-10293.

Sowa, N.A., Voss, M.K., Zylka, M.J. (2010). Recombinant ecto-5’-nucleotidase (CD73) has long lasting antinociceptive effects that are dependent on adenosine A1 receptor activation.  Mol. Pain. 6:20.

Sowa, N.A., Taylor-Blake, B., Zylka, M.J. (2010). Ecto-5’-nucleotidase (CD73) inhibits nociception by hydrolyzing AMP to adenosine in nociceptive circuits.  J. Neurosci. 30:2235-2244.

Taylor-Blake, B., Zylka, M.J. (2010). Prostatic acid phosphatase is expressed in peptidergic and nonpeptidergic nociceptive neurons of mice and rats. PLOS One 5(1):e8674. doi:10.1371/journal.pone.0008674.

Wang, H., Zylka, M.J. (2009). Mrgprd-expressing polymodal nociceptive neurons innervate most known classes of substantia gelatinosa neurons. J. Neurosci. 29:13202-13209.

Rau, K., McIlwrath, S., Wang, H., Lawson, J. Jankowski, M., Zylka, M.J., Anderson, D.J., Koerber, H.R. (2009). Mrgprd enhances excitability in specific populations of cutaneous murine polymodal nociceptors. J. Neurosci., 29:8612-8619.

Larsen, R.S., Zylka, M.J., Scott, J.E. (2009). A high throughput assay to identify small molecule modulators of prostatic acid phosphatase.  Current Chemical Genomics, 3:42-49.

Cavanaugh, D., Lee, H., Lo, L., Shields, S., Zylka, M.J., Basbaum, A.I., Anderson, D.J. (2009). Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli. Proc. Natl. Acad. Sci. USA, 106:9075-9080.

Willard, F.S., Willard, M.D., Kimple, A.J., Soundararajan, M., Oestreich, E.A., Li, X., Sowa, N.A., Kimple, R.J., Doyle, D.A., Der, C.J., Zylka, M.J., Snider, W.D., Siderovski, D.P. (2009). Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector.  PLOS One, 4(3): e4884. doi:10.1371/journal.pone.0004884.

Sowa, N.A., Vadakkan, K., Zylka, M.J. (2009). Recombinant mouse PAP has pH-dependent ectonucleotidase activity and acts through A1-adenosine receptors to mediate antinociception.  PLOS One, 4(1): e4248. doi:10.1371/journal.pone.0004248.

Zylka, M.J.*#, Sowa, N.A.*, Taylor-Blake, B., Twomey, M.A., Herrala, A., Voikar, V., Vihko, P#. (2008). Prostatic acid phosphatase is an ectonucleotidase and suppresses pain by generating adenosine.  Neuron 60:111-122.  # = co-senior authors.

Dussor, G., Zylka, M.J., Anderson, D.J., McCleskey, E.W. (2008). Cutaneous sensory neurons expressing the Mrgprd receptor sense extracellular ATP and are putative nociceptors.  J. Neurophysiol. 99:1581-1589.

Campagnola, L.*, Wang, H.*, Zylka, M.J. (2008). Fiber-coupled light-emitting diode for localized photostimulation of neurons expressing channelrhodopsin-2.  J. Neurosci Methods 169, 27-33.

Liu, Y., Yang, F., Okuda, T., Dong, X., Zylka, M.J., Chen, C., Anderson, D.J., Kuner, R., Ma, Q. (2008).  Mechanisms of compartmentalized expression of Mrg class G-protein-coupled sensory receptors.  J. Neurosci. 28, 125-132.  

Liu, Q., Vrontou, S., Rice, F.L., Zylka, M.J., Dong, X., Anderson, D.J. (2007).  Molecular genetic visualization of a rare subset of unmyelinated sensory neurons that may detect gentle touch.  Nature Neurosci. 10, 946-948.

Zylka, M.J. (2005). Nonpeptidergic circuits feel your pain.  Neuron 47, 771-772.

Lee, J., Zylka, M.J., Anderson, D.J., Burdette J.E., Woodruff, T.K., Meade, T.J. (2005).  A steroid-conjugated contrast agent for magnetic resonance imaging of cell signaling.  J. Am. Chem. Soc. 127, 13164-13166.

Zylka, M.J., Rice, F.L., Anderson, D.J. (2005).  Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd.  Neuron 45,17-25.

Zylka, M.J., Dong, X., Southwell, A.L., and Anderson, D.J. (2003). Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family.  Proc. Natl. Acad. Sci. USA 100, 10043-10048.

Han, S-K., Dong, X., Hwang, J-I., Zylka, M.J., Anderson, D.J., and Simon, M.I. (2002). Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide related peptides through the Gq/11 pathway.  Proc. Natl. Acad. Sci. USA 99, 14740-14745.

Dong, X., Han, S-K., Zylka, M.J., Simon, M.I., and Anderson, D.J. (2001). A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons.  Cell 106, 619-632.

Zylka, M.J., and Reppert, S.M. (1999). Discovery of a putative heme-binding protein family (SOUL/HBP) by two-tissue suppressive subtractive hybridization and database searches. Molecular Brain Research 74, 175-181.

Kume, K.*, Zylka, M.J.*, Sriram, S.*, Shearman, L.P.*, Weaver, D.R., Jin, X.J., Maywood, E.S., Hastings, M.H., and Reppert, S.M. (1999). mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop.  Cell 98, 193-205.

Shearman, L.P., Zylka, M.J., Reppert, S.M., and Weaver, D.R. (1999). Expression of basic helix-loop-helix/PAS genes in the mouse suprachiasmatic nucleus.  Neuroscience 89, 387-397.

Jin, X.*, Shearman, L.P.*, Weaver, D.R., Zylka, M.J., De Vries, G.J., and Reppert, S.M. (1999). A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock.  Cell 96, 57-68.

Zylka, M.J., Shearman, L.P., Levine, J.D., Jin, X., Weaver, D.R., and Reppert, S.M. (1998). Molecular analysis of mammalian Timeless. Neuron 21, 1115-1122.

Zylka, M.J.*, Shearman, L.P.*, Weaver, D.R., and Reppert, S.M. (1998). Three period homologs in mammals:  Differential light responses in the suprachiasmatic circadian clock and oscillating transcripts outside of brain.  Neuron 20, 1103-1110.

Solow, B., Bischoff, K.M., Zylka, M.J., and Kennelly, P.J. (1998). Archaeal phosphoproteins.  Identification of a hexosephosphate mutase and the [alpha]-subunit of succinyl-CoA synthetase in the extreme acidothermophile Sulfolobus solfataricus. Protein Science 7, 105-111.

Shearman, L.P.*, Zylka, M.J.*, Weaver, D.R., Kolakowski, L.F. Jr., and Reppert, S.M. (1997). Two period homologs:  Circadian expression and photic regulation in the suprachiasmatic nuclei. Neuron 19, 1261-1269.

Chik, C.L., Liu, Q.Y., Li, B., Klein, D.C., and Zylka, M. (1997). Alpha(1D) L-type calcium channel currents – inhibition by beta-adrenergic agonist and pituitary adenylate cyclase-activating polypeptide (PACAP) in rat pinealocytes.  J. Neurochem. 68, 1078-1087.

Zylka, M.J., and Schnapp, B.J.  (1996). Optimized filter set and viewing conditions for the S65T mutant of GFP in living cells.  Biotechniques 21, 220-226.

Weller, J.L., Jaffe, H., Roseboom, P.H., Zylka, M.J., and Klein, D.C. (1996). 2D-PAGE analysis–adrenergically regulated pineal protein AIP37/6 is a phosphorylated isoform of cytosolic malate dehydrogenase.  Brain Research 713, 8-16.